I study the social and genetic causes of human diseases and traits
PhD Research
Polygenic Scores, Socioeconomic Status, & Prostate Cancer
Prostate cancer is the second most common cancer in men with the highest rates occurring in African American men. While the relationship with genetics is well-known, little is known about the environmental causes of prostate cancer.
In my study, I analyzed the role of germline genetics, neighborhood socioeconomic status, and their gene-by-environment interaction on prostate cancer risk.
Recessive Disorders & Natural Selection
There are over 2,600 disorders caused by having mutations in a single gene, such as Cystic Fibrosis and Sickle Cell Anemia. While the effects of these disorders are severe, it is believed that these genes only affect individuals with 2 mutations.
In my research, I use natural selection to investigate if these “recessive genes” actually affecting a multitude of other traits
Pre-Doctoral Research
Genetic Modifiers of Blood Lipids
Cholesterol and triglyceride levels are influenced by both genetics and lifestyle. In this study, I worked with a large international team to identify genetic changes that affect blood lipid levels in people from different backgrounds. By combining information about DNA, gene activity, and how genes are regulated, we were able to pinpoint which genes might be responsible for changes in cholesterol and other lipids.
This research helps explain why some people are more likely to develop heart disease and how genetic studies can guide prevention and treatment strategies.
Developing Resources for Comparative Biology
Many discoveries in human biology come from studying mice, which share most of their genes with us. I helped build and improve a database that connects mouse genes and traits to their human counterparts. This resource allows scientists to explore how specific genes work across species and how mouse research can inform our understanding of human diseases.
Our goal was to make genetic and biological information easier to access, helping researchers translate findings from model organisms into insights about human health.